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AssigneesMassachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., Icahn School of Medicine at Mount Sinai
InventorsYongTae Kim, Zahi Fayad, Willem J. Mulder, Edward Fisher, Francois Fay, Omid C. Farokhzad, Robert Langer
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Methods for making particles, such as nanoparticles, devices useful in the methods, and particles made by the method are described herein. The methods involves the use of microfluidic device, such that upon mixing solutions of the materials to form the particles (or a solution of the material or materials to form the particles and a non-solvent for the material or materials) at least two symmetrical microvortices are formed simultaneously. The method can be used to prepare polymeric or non-polymeric particles and hybrid particles, such as lipid-polymer hybrid particles, as well as such particles containing one or more agents associated with the particles.
A method of making nanoparticles comprising mixing in a microfluidic device comprising a central fluid inlet channel and two outer fluid inlet channels, wherein the channels converge in a mixing channel prior to the outlet, a solution of one or more materials selected from polymers and lipids with a non-solvent for the one or more materials to form a three-dimensional pattern comprising at least two symmetrical microvortices and focusing the pattern downstream to form the nanoparticles,
Dependencies are inferred from the claim text.