Multilayer thin film drug delivery device and methods of making and using the same

A multilayer thin film medical device, comprising:

• a first layer comprising a polymer, wherein the polymer is selected from the group consisting of poly(ε-caprolactone) (PCL), polylactide (PLA), polyglycolide (PGA), poly(DL-lactide-co-glycolide) (PLGA), and poly(DL-lactide-co-ϑ-caprolactone) (DLPLCL), wherein the first layer does not include a water soluble polymer, wherein the first layer comprises a first surface and a second surface opposite the first surface;
• a layer of lyophilized bioactive agent in absence of a polymer;
• and
• a second layer comprising a polymer, wherein the polymer is selected from the group consisting of poly(ε-caprolactone) (PCL), polylactide (PLA), polyglycolide (PGA), poly(DL-lactide-co-glycolide) (PLGA), and poly(DL-lactide-co-ϑ-caprolactone) (DLPLCL), wherein the second layer does not include a water soluble polymer, wherein the second layer comprises a first surface and a second surface opposite the first surface;
• wherein the bioactive agent is positioned only between the second surface of the first layer and the first surface of the second layer,
• wherein the second surface of the first layer is in contact with the first surface of the second layer at the periphery of the multilayer thin film medical device and wherein the contact extends from the periphery of the device to a periphery of the location at which the bioactive agent is positioned thereby sealing the bioactive agent inside the multilayer thin film medical device, wherein the contact does not extend to regions in interior of the device,
• wherein the bioactive agent is not positioned between the first and the second layers at the periphery of the multilayer thin film medical device,
• wherein the device has an area between 1 mm2 and 36 mm2,
• wherein the device has a thickness between 10 μm and 500 μm, and
• wherein the device provides a zero order release of the bioactive agent over at least 10 days following administration.