System and method for photo-thermal analysis of immunoassay tests
OwnerPouya Rezai, Nima Tabatabaei +1inventors
InventorsPouya Rezai, Nima Tabatabaei, Ashkan Ojaghi
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Abstract
A system and method for photo-thermal imaging of a lateral flow immunoassay (LFA) device are provided. The system includes an intensity modulated heat source directed at a surface of the LFA device to selectively excite chromophore particles of interest and a thermal capture device configured to capture thermal waves emitted from the surface of the LFA device as a radiometric signal. A computing device, in communication with the thermal capture device, receives the radiometric signal and executes lock-in demodulation to detect surface or subsurface inhomogeneities of the LFA device.
Claims18
A system for photo-thermal imaging of a lateral flow immunoassay (LFA) device, the system comprising:
- an intensity modulated heat source directed at a surface of the LFA device to selectively excite chromophore particles of interest;
- a thermal capture device configured to capture thermal waves emitted from the surface of the LFA device as a radiometric signal;
- and
- a computing device, in communication with the thermal capture device, to receive the radiometric signal and execute lock-in demodulation to detect surface or subsurface inhomogeneities of the LFA device, the lock-in demodulation comprising evaluating an alternating current (AC) portion of the radiometric signal.
A method for photo-thermal imaging of a lateral flow immunoassay (LFA) device, the method comprising:
- thermally exciting, by intensity modulation, chromophore particles on or proximate a surface of the LFA device to produce emission of thermal waves;
- capturing the thermal waves as a radiometric signal;
- and
- performing lock-in demodulation on the radiometric signal to detect surface or subsurface inhomogeneities of the LFA device, the lock-in demodulation comprising evaluating an alternating current (AC) portion of the radiometric signal.
Dependencies are inferred from the claim text.