Methods of assessing a risk of developing necrotizing meningoencephalitis
AssigneesThe Translational Genomics Research Institute, University of Georgia Research Foundation, Inc.
InventorsMatthew Huentelman, Scott Schatzberg, Renee Barber
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Abstract
The present invention provides method of classifying a subject into a necrotizing meningoencephalitis (NME) disease risk group. The method may include assessing the presence of one or more marker (e.g., SNPs or risk loci) in a sample from the subject. For example, detection of the presence of one or more markers that are associated with an increased risk of NME can indicate that the subject should be classified into a risk group.
Claims8
A method for treating a canine subject for necrotizing meningoencephalitis (NME), the method comprising:
- extracting genomic DNA from a sample from the canine subject;
- assaying the genomic DNA for one or more single nucleotide polymorphisms (SNPs), wherein the SNPs comprise BICF2G630168244 corresponding to position 74522353 on canine chromosome 4 and rs8954494 corresponding to position 53338796 on canine chromosome 15;
- detecting an A allele at BICF2G630168244 and a G allele at rs8954494 in the genomic DNA from the sample;
- and
- administering an effective amount of an immunosuppressive treatment to the canine subject having the A allele at BICF2G630168244 and a G allele at rs8954494 in the genomic DNA from the sample.
A method for breeding a canine subject to reduce propensity to necrotizing meningoencephalitis (NME) in progeny resulting from the breeding, the method comprising:
- extracting genomic DNA from a sample from the canine subject;
- assaying the genomic DNA for one or more single nucleotide polymorphisms (SNPs), wherein the SNPs comprise BICF2G630168244 corresponding to position 74522353 on canine chromosome 4 and rs8954494 corresponding to position 53338796 on canine chromosome 15;
- detecting a T allele at BICF2G630168244 and an A allele at rs8954494 in the genomic DNA from the sample;
- and
- breeding the canine subject with the T allele at BICF2G630168244 and the A allele at rs8954494 in the genomic DNA from the sample.
Dependencies are inferred from the claim text.