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US 10,769,820 B2Granted
System and method for model-based reconstruction of quantitative images
AssigneeMayo Foundation for Medical Education and Research
InventorsJoshua D. Trzasko, Armando Manduca
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Abstract
A system and method for estimating a physiological parameter from data acquired with a medical imaging system includes acquiring data with the medical imaging system. A physiological parameter is estimated from the acquired data using an iterative estimation in which a model of the medical imaging system is decoupled from a physics-based model of the acquired data.
Claims20
A system for generating medical images comprising:
- a communications connection configured to receive image data acquired from a subject using a medical imaging system;
- a processor configured to receive the image data and to:
- a) estimate a physiological parameter from the image data by inputting the image data to an estimation model comprising a model of the medical imaging system that is decoupled from a physics-based model of the image data, generating output as the estimate of the physiological parameter, wherein the physics-based model comprises a nonlinear signal model functional that models the image data such that the image data have a nonlinear dependence on at least one parameter of the physics-based signal model, and the model of the medical imaging system is actively decoupled from the physics-based model by applying a multi-level splitting routine to the model of the medical imaging system and the physics-based model;
- b) iteratively minimize a cost function that includes the model of the medical imaging system and the physics-based model of the acquired data to quantify the physiological parameter of the subject from the image data;
- and
- c) reconstruct a set of medical images of the subject from the image data at least including the physiological parameter of the subject.
3 more elements
A method for estimating a physiological parameter from data acquired with a medical imaging system, the steps of the method comprising:
- a) acquiring data with the medical imaging system;
- b) estimating a physiological parameter from the acquired data by inputting the acquired data to an estimation model comprising a model of the medical imaging system that is decoupled from a physics-based model of the acquired data, generating output as the estimate of the physiological parameter, wherein the physics-based model comprises a nonlinear signal model functional that models the acquired data such that the acquired data have a nonlinear dependence on at least one parameter of the physics-based signal model, and the model of the medical imaging system is actively decoupled from the physics-based model by applying a multi-level splitting routine to the model of the medical imaging system and the physics-based model;
- and
- c) reconstructing a set of medical images from the data, the medical images at least including the physiological parameter.
1 more element
A magnetic resonance imaging (MRI) system, comprising:
- a magnet system configured to generate a polarizing magnetic field about at least a portion of a subject arranged in the MRI system;
- a magnetic gradient system including a plurality of magnetic gradient coils configured to apply at least one magnetic gradient field to the polarizing magnetic field;
- a radio frequency (RF) system configured to apply an RF field to the subject and to receive magnetic resonance signals from the subject using a coil array;
- a computer system processor programmed to:
- control the magnetic gradient system and the RF system to acquire image data;
- estimate a physiological parameter from the image data by inputting the image data to an estimation model comprising a model of the MRI system that is decoupled from a physics-based model of the image data, generating output as the estimate of the physiological parameter, wherein the physics-based model comprises a nonlinear signal model functional that models the image data such that the image data have a nonlinear dependence on at least one parameter of the physics-based signal model, and the model of the medical imaging system is actively decoupled from the physics-based model by applying a multi-level splitting routine to the model of the medical imaging system and the physics-based model;
- and
- generate a quantitative image of the subject with the physiological parameter.
5 more elements
Dependencies are inferred from the claim text.