Tenofovir detection assay
AssigneeTrustees of Boston University
InventorsCatherine M. Klapperich, George Woodman Pratt, IV, Andy Fan
Life of this patent
Estimating the term…
Abstract
Disclosed herein are antibodies capable of specifically binding to tenofovir (TFV), a key small molecule drug for both the treatment and prevention of HIV, and a competitive lateral flow assay that uses these antibodies to monitor urine samples for the presence of the drug. The assay can be deployed as a point-of-care device for adherence monitoring.
Claims18
A polyclonal antibody composition comprising a heterogeneous population of mammalian antibodies that specifically bind tenofovir (TFV) and a conjugate of TFV-SH and sulfosuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate (sulfo-SMCC) modified bovine serum albumin (BSA),
- wherein the heterogeneous population of mammalian antibodies is generated against
- wherein R is keyhole limpet hemocyanin (KLH).
Dependencies are inferred from the claim text.