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US 10,768,160 B2Granted
Artificial gut simulator and method
AssigneeRegents of the University of Minnesota
InventorRonald A. Siegel
Life of this patent
Estimating the term…
Abstract
An artificial gut simulator and methods are shown. In one example, the artificial gut simulator and methods provide accurate dissolution data by removing detected test sample material from the tester over time.
Claims17
An artificial gut simulator, comprising:
- a test sample dissolution container;
- a stirring device within the test sample dissolution container;
- a conduit passing through the test sample dissolution container, the conduit including a semi-permeable membrane adapted to allow the transport of a selected test sample component through the semi-permeable membrane, while excluding other components from within the test sample dissolution container;
- a pump to drive an amount of medium through the conduit over time;
- and
- a detector to quantify an amount of the selected test sample component over time that has passed from the test sample dissolution container, through the semi-permeable membrane, and into the medium.
3 more elements
A method of drug dissolution testing, comprising:
- placing a drug test sample in a test sample dissolution container;
- pumping a medium through a conduit that passes through the test sample dissolution container, wherein the conduit includes a semi-permeable membrane;
- passing a selected drug test sample component through the semi-permeable membrane, while excluding other components from within the test sample dissolution container;
- and
- quantifying an amount of the selected drug test sample component over time that has passed from the test sample dissolution container, through the semi-permeable membrane, into the medium, and out of the test sample dissolution container.
2 more elements
Dependencies are inferred from the claim text.