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US 10,768,139 B2Granted
Electrochemical probe
AssigneeThe Francis Crick Institute Limited
InventorsRomeo-Robert Racz, Mihaly Kollo, Andreas Schaefer
Life of this patent
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Abstract
An electrochemical probe comprises a wire bundle including two or more wire electrodes made of conducting material arranged alongside each other, and insulating material surrounding the electrodes. An impedance reducing layer of metal or metal oxide nano-structures is deposited on tips of the wire electrodes at a first end of the bundle. A functionalization layer is deposited on the impedance reducing layer at the first end of the bundle. Such a probe is particularly useful for electrochemical sensing applications such as neuronal scanning.
Claims17
An electrochemical probe comprising:
- a wire bundle comprising a plurality of wire electrodes arranged alongside each other;
- each of the plurality of wire electrodes comprising conducting material and insulating material surrounding the conducting material;
- and
- an impedance reducing layer of metal nano-structures or metal oxide nano-structures deposited on a polished surface of tips of the plurality of wire electrodes at a first end of the wire bundle, wherein the metal nano-structures or the metal oxide nano-structures have a unit width less than or equal to 500 nm;
- and
- a functionalization layer deposited on the impedance reducing layer at said first end of the wire bundle;
- wherein:
- along sides of the plurality of wire electrodes, said insulating material contacts the conducting material without an intervening layer of the metal nano-structures or metal oxide nano-structures;
- and
- for each of the plurality of wire electrodes:
- a diameter of the wire electrode is less than or equal to 25 μm;
- the first end of the wire electrode is tapered to meet at a point;
- and,
- the impedance reducing layer does not extend beyond the diameter of the wire electrode.
11 more elements
A method of manufacturing an electrochemical probe, comprising:
- forming a wire bundle comprising a plurality of wire electrodes arranged alongside each other, each of the plurality of wire electrodes comprising conducting material and insulating material surrounding the conducting material;
- and
- after the insulating material is already provided around the conducting material and the plurality of wire electrodes are already formed into said wire bundle, depositing an impedance reducing layer of metal nano-structures or metal oxide nano-structures on tips of the plurality of wire electrodes at a first end of the wire bundle;
- and
- depositing a functionalization layer on the impedance reducing layer at said first end of the wire bundle;
- wherein the metal nano-structures or the metal oxide nano-structures have a unit width less than or equal to 500 nm;
- along sides of the wire electrodes, said insulating material contacts the conducting material without an intervening layer of the metal nano-structures or metal oxide nano-structures;
- and
- for each of the plurality of wire electrodes:
- a diameter of the wire electrode is less than or equal to 25 μm;
- the first end of the wire electrode is tapered to meet at a point;
- and,
- the impedance reducing layer does not extend beyond the diameter of the wire electrode.
10 more elements
An electrochemical probe comprising:
- a wire bundle comprising a plurality of wire electrodes arranged alongside each other,
- each of the plurality of wire electrodes comprising conducting material and insulating material surrounding the conducting material;
- and
- an impedance reducing layer of gold nano-structures deposited on a polished surface of tips of the plurality of wire electrodes at a first end of the wire bundle, wherein
- the gold nano-structures have a unit width less than or equal to 500 nm;
- and
- along sides of the plurality of wire electrodes, said insulating material contacts the conducting material without an intervening layer of the gold nano-structures;
- and
- for each of the plurality of wire electrodes:
- a diameter of the wire electrode is less than or equal to 25 μm;
- the first end of the wire electrode is tapered to meet at a point;
- and
- the impedance reducing layer does not extend beyond the diameter of the wire electrode.
10 more elements
Dependencies are inferred from the claim text.