Multi-modal optical imaging system for tissue analysis

A modular system for organic sample analysis of tissue, comprising:

• a sample stage comprising a support platform, a motorized positioning assembly mounted on said support platform, the support platform comprising a vibrationally damped base, the vibrationally damped base preventing noise in an optical signal, and a sample holder mounted on said motorized positioning assembly upon which a tissue sample is placed, the motorized positioning assembly comprising a motorized stage driver and at least one actuator, the at least one actuator comprising at least one of:
• a motorized stage actuator, a DC motor, a stepper motor, and a piezoelectric effect actuator, the motorized stage driver providing necessary electrical driving signals for the motorized stage actuators and collecting electrical signals from at least one sensor, and the at least one sensor providing information relating to a state of the motorized positioning assembly;
• a probe support rack mounted on said support platform;
• a plurality of bio-imaging probes mounted on said probe support rack with said bio-imaging probes arranged in a pre-defined geometry with respect to one another, at least one bio-imaging probe having a field of view independent of all other bio-imaging probes;
• a computer controller coupled with said motorized positioning mechanism assembly and said plurality of bio-imaging probes, said computer controller programmed with instructions for instructing said motorized positioning assembly to move said sample holder, having the tissue sample located thereon, to positions in the field of view of each bio-imaging probe where the tissue sample is individually analyzable by each of said bio-imaging probes, said computer controller comprising means for storing an imaging data from each said bio-imaging probe, and said computer controller programmed with instructions for spatially correlating imaging data of a selected volume of interest with the imaging data obtained from at least one other bio-imaging probe and storing said spatially correlated imaging data in said storing means;
• an enclosure accommodating the plurality of bio-imaging probes and motorized positioning assembly;
• and
• a ventilation system configured to circulate fresh air into the enclosure.