Back to results
US 10,767,192 B2Granted
Baculovirus system for the expression of a gene therapy vector
AssigneeGenethon
InventorsLionel Galibert, Otto-Wilhelm Merten, Aurelien Jacob
Life of this patent
Estimating the term…
Abstract
The invention relates to a recombinant baculoviral genome useful for the production of viral vectors for gene therapy, allowing said production from a single infection.
Claims21
A recombinant baculovirus genome comprising:
- (i) one or more expression cassettes comprising adeno-associated virus (AAV) rep and cap genes under the control of a promoter suitable for expression of said genes in an insect host cell, and
- (ii) a recombinant genome of an AAV vector,
- wherein said one or more expression cassettes and said recombinant genome of an AAV vector are each inserted into a locus selected from the egt locus and the polyhedrin locus.
Dependencies are inferred from the claim text.