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US 10,767,181 B2Granted
Oligomers and oligomer conjugates
AssigneeHoffmann-La Roche Inc.
InventorsHassan Javanbakh, Søren Ottosen, Morten Lindow
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Abstract
The present invention relates to an oligomer conjugate for use in the treatment of a viral disorder. The oligomer conjugate comprises: a) an oligomer capable of modulating a target sequence in HBx and/or HBsAg of Hepatitis B Virus (HBV) to treat said viral disorder; and b) a carrier component capable of delivering the oligomer to the liver which is linked, preferably conjugated, to the oligomer.
Claims13
An oligomer conjugate comprising:
- a) at least a first oligomer that is 10 to 20 nucleotides in length and comprises a nucleotide sequence selected from the group consisting of SEQ ID NO:
- 24;
- 25;
- 26;
- 27;
- 28;
- 183;
- 184;
- 185;
- 186;
- 187;
- 188;
- 189;
- 190;
- 191;
- 192;
- 193;
- 194;
- 195;
- 196 and 197;
- b) a carrier component comprising an asialoglycoprotein receptor (ASGP-R) targeting moiety, wherein the carrier component is covalently attached to the first oligomer.
18 more elements
Dependencies are inferred from the claim text.