Compositions and methods of using piRNAS in cancer diagnostics and therapeutics
AssigneeYale University
InventorYong Zhu
Life of this patent
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Abstract
Aberrantly expressed piRNAs, genetically associated piRNAs and their relationship with cancer risk and severity are provided. Compositions and methods of using piRNA for treating cancer are provided. Methods of diagnosing subjects and determining the efficacy of active agents for treating cancer are also provided. Methods of correlating variant piRNA to cancer are also disclosed.
Claims20
A method of treating a subject for liver cancer comprising administering the subject an effective amount of a pharmaceutical composition comprising a compound that increases the level of piR-37213 or a mimic thereof in cells of the liver cancer.
A method of treating a subject for liver cancer comprising administering the subject an effective amount of a pharmaceutical composition comprising a compound selected from a nucleic acid encoding wildtype piR-37213, wildtype piR-37213, or a piR-37213 mimic.
A method of treating a subject for liver cancer comprising administering the subject an effective amount of a pharmaceutical composition comprising wildtype piR-37213 or a mimic thereof incorporated into or encapsulated by liposomes.
Dependencies are inferred from the claim text.