Sterol regulatory element binding protein (SREBP) chaperone (SCAP) iRNA compositions and methods of use thereof

A double stranded ribonucleic acid (RNAi) agent for inhibiting expression of a sterol regulatory element binding protein (SREBP) chaperone (SCAP) gene, wherein said double stranded RNAi agent comprises a sense strand complementary to an antisense strand, wherein said antisense strand comprises a region complementary to nucleotides 1132-1156 of SEQ ID NO:1, wherein each strand is about 14 to about 30 nucleotides in length, wherein said double stranded RNAi agent is represented by formula (III):

• sense:5′np-Na-(XXX)i-Nb-YYY-Nb-(ZZZ)i-Na-nq3′
• antisense:3′np′-Na′-(X′X′X′)k-Nb′-Y′Y′Y′-Nb′-(Z′Z′Z′)l—Na′-nq′5′ (III)
• wherein:
• j, k, and 1 are each independently 0 or 1;
• p, p′, q, and q′ are each independently 0-6;
• each Na and Na′ independently represents an oligonucleotide sequence comprising 0-25 nucleotides which are either modified or unmodified or combinations thereof, each sequence comprising at least two differently modified nucleotides;
• each Nb and Nb′ independently represents an oligonucleotide sequence comprising 0-10 nucleotides which are either modified or unmodified or combinations thereof;
• each np, np′, nq, and nq′, each of which may or may not be present, independently represents an overhang nucleotide;
• XXX, YYY, ZZZ, X′X′X′, Y′Y′Y′, and Z′Z′Z′ each independently represent one motif of three identical modifications on three consecutive nucleotides;
• modifications on Nb differ from the modification on Y and modifications on Nb′ differ from the modification on Y′;
• and
• wherein the sense strand is conjugated to at least one ligand.