Hyaluronic acid conjugates and uses thereof

A graft polymer of a hyaluronic acid polymer and a N-isopropylacrylamide based polymer wherein the hyaluronic acid polymer and the N-isopropylacrylamide based are conjugated through at least one linker L of Formula (II):

• wherein one of Ra and Rb is covalently linked to the N-isopropylacrylamide based polymer and one of Ra and Rb is covalently linked to the hyaluronic acid polymer and when Ra or Rb is covalently linked to the N-isopropylacrylamide based polymer, it is equal to R1 and when Ra or Rb is covalently linked to the hyaluronic acid polymer, it is equal to R3, wherein R1 is a group selected from (CH2)x—NH(CH2)y—S—, —(CH2)x—NH—O—C(O)—(CH2)y—S—, —(CH2)x—NH—(CH2)y—C(O)—NH—(CH2)z—S—, —(CH2)x—O—C(O)—CR7R8—, —C(O)—(CH2)x—C(O)—NH—(CH2)z—S and an optionally substituted polyethylene chain wherein R7 and R8 are optionally substituted C1-C6 alkyl;
• R3 is a group -E-G-L1- wherein E is either absent or selected from —C(O)—NR9—, —C(O)—O— and —C(O)—, G is linker group selected from optionally substituted C1-C20 alkyl, optionally substituted polyethylene glycol (PEG) chain, optionally substituted acylamino C1-C6 alkyl, optionally substituted acyl C1-C6 alkyl, optionally substituted aminocarbonyl C1-C6 alkyl and optionally substituted C1-C6 alkoxy and L1 is selected from —NR10C(O)—, —C(O)—NR10—, —C(O)—O— and —C(O)— wherein R9 and R10 are independently selected from H and optionally substituted C1-C6 alkyl;
• A is an optionally substituted C5-C10-cycloalkyl, or optionally substituted heterocycloalkyl ring wherein R5 represents one or more substituent(s) independently selected from H, optionally substituted alkoxy and optionally substituted C1-C6 alkyl;
• x, y and z are integers independently selected from 1 to 20 or any pharmaceutically acceptable salts thereof.