Modified carbohydrates, compositions comprising the same, and methods of making and using the same
AssigneesWake Forest University Health Sciences, Wake Forest University
InventorsMark E. Welker, Emmanuel C. Opara, Surya R. Banks, Amber N. Weissenfluh
Life of this patent
Estimating the term…
Abstract
Modified alginates are described herein along with hydrogels comprising the same. A modified alginate may be prepared by reacting alginate and an aromatic compound (e.g., an aromatic amine) and/or pH sensitive compound. The modified alginates, hydrogels, and/or methods described herein may be used to coat and/or encapsulate at least a portion of a bioactive substance, optionally for oral delivery in humans and other animals.
Claims20
A compound comprising at least one unit having a structure of Formula I:
- wherein
- Y is absent or a C1-C4 alkyl or C1-C4 alkenyl;
- R1 is each independently selected from the group consisting of —H, —OH, —NH2, —COOH, —NO2, —CN, —Br, —Cl, —F, —C1-C6 alkylhalide, unsubstituted or substituted —C1-C6 alkyl, unsubstituted or substituted —C1-C6 alkenyl, —SO2H, —SO3H, —COCH3, —Si(OH)3, —SO2NH2, —PO(OR′)2, and —B(OH)2, wherein R′ is unsubstituted or substituted alkyl, alkenyl, alkynyl, or aryl;
- n is from 1 to 1,000,000;
- and
- o is 1, 2, 3, 4, or 5,
- wherein at least one R1 is in the para position and is selected from the group consisting of —NH2, —COOH, —NO2, —CN, —Br, —Cl, —F, —C1-C6 alkylhalide, unsubstituted or substituted —C1-C6 alkyl, unsubstituted or substituted —C1-C6 alkenyl, —SO2H, —SO3H, —COCH3, —Si(OH)3, —SO2NH2, —PO(OR′)2, and —B(OH)2, and wherein R′ is unsubstituted or substituted alkyl, alkenyl, alkynyl, or aryl, and
- wherein the compound is an alginate polymer.
A compound comprising at least one unit having a structure of Formula II:
- wherein
- Y is absent or a C1-C4 alkyl or C1-C4 alkenyl;
- R1 is each independently selected from the group consisting of —H, —OH, —NH2, —COOH, —NO2, —CN, —Br, —Cl, —F, —C1-C6 alkylhalide, unsubstituted or substituted —C1-C6 alkyl, unsubstituted or substituted —C1-C6 alkenyl, —SO2H, —SO3H, —COCH3, —Si(OH)3, —SO2NH2, —PO(OR′)2, and —B(OH)2, wherein R′ is unsubstituted or substituted alkyl, alkenyl, alkynyl, or aryl;
- n is from 1 to 1,000,000;
- and
- o is 0, 1, 2, 3, 4, or 5, and
- wherein the compound is an alginate polymer.
Dependencies are inferred from the claim text.