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US 10,766,964 B2Granted
Compositions and methods for treating and preventing inflammation
AssigneeRsem, Limited Partnership
InventorsPrzemyslaw Sapieha, Normand Beaulieu
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Abstract
The present invention provides novel compounds compositions and methods for (i) treating or preventing inflammation; and (ii) preventing or reducing hyperactivation of innate immune response, by inhibiting NRP1-dependent cell-signaling. Also provided are compounds, composition, and methods of specifically inhibiting SEMA3A-mediated cell signaling.
Claims19
A fusion polypeptide comprising a neuropilin-1 (NRP1) polypeptide consisting of an amino acid sequence having at least 90% identity with residues 22-424 of SEQ ID NO:
- 107, wherein said fusion polypeptide does not comprise the b2 and c domains of native human NRP1 and has a purification tag linked to said NRP1 polypeptide.
Dependencies are inferred from the claim text.