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US 10,766,959 B2Granted
Anti-C10ORF54 antibodies and uses thereof
AssigneePierre Fabre Medicament
InventorsJohn Lippincott, Edward Thein Htun Van Der Horst, Sung Young Kim, Leonard G Presta, Jan-Willem Theunissen
Life of this patent
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Abstract
The present disclosure relates generally to anti-C10orf54 antibodies, including antibody-drug conjugates comprising the antibodies, and methods of their use.
Claims15
An isolated antibody or antigen-binding fragment thereof that binds to a C10orf54 protein, comprising:
- a heavy chain comprising the following three CDRs, respectively CDR-H1 having the sequence SEQ ID NO:
- 1296, CDR-H2 having a sequence selected from SEQ ID NO:
- 1358, SEQ ID NO. 1556, SEQ ID NO. 1557, SEQ ID NO. 1558, and SEQ ID NO. 1559, and CDR-H3 having the sequence SEQ ID No. 1393;
- and
- a light chain comprising the following three CDRs, respectively CDR-L1 having the sequence SEQ ID No. 1435, CDR-L2 having a sequence selected from SEQ ID NO:
- 1476, SEQ ID NO. 1630, SEQ ID NO. 1631, SEQ ID NO. 1632, and SEQ ID NO. 1633, and CDR-L3 having the sequence SEQ ID No. 1499.
3 more elements
Dependencies are inferred from the claim text.