Loading patent…
AssigneeSanofi
InventorsGary Shapiro, Kevin Brower, Patrick Finn, Richard C. Gregory, Rao Koduri, Feng Liu, Natalia Malkova, Parminder Mankoo, Jack R. Pollard, Huawei Qiu, Joachim Theilhaber, Christopher Winter, Marcella Yu
Estimating the term…
The invention provides an improved pan-TGF-β antibody for treatment of conditions that are mediated by TGF-β, including autoimmune diseases, fibrotic conditions, and cancers. Also provided are methods and uses of the antibody in conjunction with other immunomodulatory agents such as an anti-PD-1 antibody.
A method of inhibiting TGF-β signal transduction in a patient in need thereof, comprising administering to the patient a therapeutic amount of an isolated monoclonal antibody, wherein the antibody binds to human TGF-β1, TGF-β2, and TGF-β3 and comprises the heavy chain complementarity-determining regions (CDR) 1-3 in SEQ ID NO:1 and the light chain CDR1-3 in SEQ ID NO:2, and wherein the antibody comprises a human IgG4 constant region having a proline at position 228 (EU numbering).
A method of treating cancer or increasing an immune response in a patient in need thereof, comprising administering to the patient (1) a therapeutically effective amount of an isolated monoclonal antibody, and (2) a therapeutically effective amount of an inhibitor of an immune checkpoint protein, wherein the antibody binds to human TGF-β1, TGF-β2, and TGF-β3 and comprises the heavy chain complementarity-determining regions (CDR) 1-3 in SEQ ID NO:1 and the light chain CDR1-3 in SEQ ID NO:2, and wherein the antibody comprises a human IgG4 constant region having a proline at position 228 (EU numbering).
A method of treating cancer in a patient in need thereof, comprising administering to the patient (1) a therapeutically effective amount of an isolated monoclonal antibody, and (2) a therapeutically effective amount of an antibody to PD-1 or PD-L1, wherein the isolated monoclonal antibody comprises a heavy chain amino acid sequence set forth in SEQ ID NO:1 and a light chain amino acid sequence set forth in SEQ ID NO:2.
Dependencies are inferred from the claim text.