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US 10,766,954 B2Granted
Therapeutic antibodies for treatment of neurodegeneration
AssigneeImago Pharmaceuticals, Inc.
InventorsIrene Griswold-Prenner, Karen Chen
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Abstract
The invention provides therapeutic antibodies and methods for treatment of diseases associated with diseases associated with aggregation of α-synuclein, e.g., in the brain of a subject. Such methods provide administration of therapeutic antibodies to elicit a beneficial immunogenic response against aggregation of α-synuclein. The methods are particularly useful for prophylactic and therapeutic treatment of diseases associated with the formation of Lewy bodies, e.g., Parkinson's disease.
Claims12
A therapeutic monoclonal antibody comprising the VL CDRs of SEQ ID NO:1, SEQ NO:2 and SEQ NO:
- 3 and comprising the VH CDRs of SEQ ID NO:4, SEQ NO:5 and SEQ NO:
- 6.
Dependencies are inferred from the claim text.