Back to results
US 10,766,940 B2Granted
Brain penetrant amylin receptor based peptides for Alzheimer's disease
AssigneeThe Governors of the University of Alberta
InventorsJack Jhamandas, Rania Soudy, Kamaljit Kaur, Wen Fu, David MacTavish, Aarti Patel
Life of this patent
Estimating the term…
Abstract
Amylin receptor antagonists capable of binding to the amylin receptor and inhibiting activity of amylin or amyloid-beta protein are provided. The amylin receptor antagonists can be administered in the form of pharmaceutical compositions or the like. Methods for preparing and using the amylin receptor antagonists for treating, preventing, or ameliorating Alzheimer's disease are also provided.
Claims5
An amylin receptor antagonist selected from the group consisting of cyclic AC253 having the amino acid sequence of SEQ ID NO:
- 2 and a peptide fragment of AC253 consisting of an amino acid sequence selected from the group consisting of SEQ ID NO:
- 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, and 16, wherein the amylin receptor antagonist is brain penetrant and capable of binding to an amylin receptor and inhibiting activity of amylin, amyloid-beta protein, or both.
Dependencies are inferred from the claim text.