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US 10,766,937 B2Granted
Compositions and methods of treating cancer
AssigneeDana-Farber Cancer Institute, Inc.
InventorYoshihiro Nakatani
Life of this patent
Estimating the term…
Abstract
The present invention provides compositions and methods of treating various disorders associated with aberrant cell growth.
Claims9
A p600 deoxyribonucleic acid (DNA) fragment consisting of a DNA sequence selected from the group consisting of SEQ ID NO:
- 7, 9, 11, 13, 15, 17, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77 and 79 wherein the p600 DNA fragment encodes a polypeptide that when expressed in a cell induces cell death.
A nanoparticle or nanosphere comprising a p600 DNA fragment consisting of a DNA sequence selected from the group consisting of SEQ ID NO:
- 3, 5, 7, 9, 11, 13 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77 and 79, wherein the DNA fragment encodes a polypeptide that when expressed in a cell induces cell death.
A p600 DNA fragment selected from the group consisting of a p600 DNA sequence comprising SEQ ID NO:
- 7 that is less than 1,500 nucleotides in length, a p600 DNA sequence comprising SEQ ID NO:
- 9 that is less than 2,000 nucleotides in length, a p600 DNA sequence comprising SEQ ID NO:
- 11 that is less than 2,900 nucleotides in length, a p600 DNA sequence comprising SEQ ID NO:
- 13 that is less than 2,200 nucleotides in length, a p600 DNA sequence comprising SEQ ID NO:
- 15 that is less than 1,800 nucleotides in length, a p600 DNA sequence comprising SEQ ID NO:
- 17 that is less than 1,900 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 21 that is less than 1,900 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 23 that is less than 1,700 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 25 that is less than 800 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 27 that is less than 1,200 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 29 that is less than 1,200 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 31 that is less than 2,200 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 33 that is less than 1,300 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 35 that is less than 1,000 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 37 that is less than 1,500 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 39 that is less than 1,500 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 41 that is less than 2,000 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 43 that is less than 1,500 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 45 that is less than 1,200 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 47 that is less than 1,500 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 49 that is less than 800 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 51 that is less than 1,200 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 53 that is less than 1,000 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 55 that is less than 1,000 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 57 that is less than 900 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 59 that is less than 800 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 61 that is less than 1,300 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 63 that is less than 1,100 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 65 that is less than 1,800 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 67 that is less than 1,500 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 69 that is less than 2,300 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 71 that is less than 2,400 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 73 that is less than 1,800 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 75 that is less than 1,600 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 77 that is less than 1,700 nucleotides in length, and a p600 DNA sequence comprising of SEQ ID NO:
- 79 that is less than 1,800 nucleotides in length, wherein the p600 DNA fragment encodes a polypeptide that when expressed in a cell induces cell death.
33 more elements
A nanoparticle or nanosphere comprising a p600 DNA fragment selected from the group consisting of a p600 DNA sequence comprising SEQ ID NO:
- 3 that is less than 2,600 nucleotides in length, a p600 DNA sequence comprising SEQ ID NO:
- 5 that is less than 2,200 nucleotides in length, a p600 DNA sequence comprising SEQ ID NO:
- 7 that is less than 1,500 nucleotides in length, a p600 DNA sequence comprising SEQ ID NO:
- 9 that is less than 2,000 nucleotides in length, a p600 DNA sequence comprising SEQ ID NO:
- 11 that is less than 2,900 nucleotides in length, a p600 DNA sequence comprising SEQ ID NO:
- 13 that is less than 2,200 nucleotides in length, a p600 DNA sequence comprising SEQ ID NO:
- 15 that is less than 1,800 nucleotides in length, a p600 DNA sequence comprising SEQ ID NO:
- 17 that is less than 1,900 nucleotides in length, a p600 DNA sequence comprising SEQ ID NO:
- 19 that is less than 2,200 nucleotides in length, and a p600 DNA sequence comprising SEQ ID NO:
- 21 that is less than 1,900 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 23 that is less than 1,700 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 25 that is less than 800 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 27 that is less than 1,200 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 29 that is less than 1,200 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 31 that is less than 2,200 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 33 that is less than 1,300 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 35 that is less than 1,000 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 37 that is less than 1,500 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 39 that is less than 1,500 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 41 that is less than 2,000 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 43 that is less than 1,500 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 45 that is less than 1,200 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 47 that is less than 1,500 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 49 that is less than 800 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 51 that is less than 1,200 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 53 that is less than 1,000 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 55 that is less than 1,000 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 57 that is less than 900 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 59 that is less than 800 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 61 that is less than 1,300 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 63 that is less than 1,100 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 65 that is less than 1,800 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 67 that is less than 1,500 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 69 that is less than 2,300 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 71 that is less than 2,400 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 73 that is less than 1,800 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 75 that is less than 1,600 nucleotides in length, a p600 DNA sequence comprising of SEQ ID NO:
- 77 that is less than 1,700 nucleotides in length, and a p600 DNA sequence comprising of SEQ ID NO:
- 79 that is less than 1,800 nucleotides in length, wherein the p600 DNA fragment encodes a polypeptide that when expressed in a cell induces cell death.
36 more elements
Dependencies are inferred from the claim text.