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AssigneeL-Base Co., Ltd.
InventorsDo Yong Jeon, Chang Hoon Moon, Ji Eun Jung
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Provided are a polypeptide having the activity of inhibiting autophagy in a cell, a composition for inhibiting autophagy in a cell, and particularly in a tumor cell, containing the polypeptide as an active ingredient, and a pharmaceutical composition containing the polypeptide, and more specifically, a composition for inhibiting autophagy in a cell containing a polypeptide inhibiting the control mechanism of autophagy as an active ingredient, and a pharmaceutical composition for preventing or treating a neoplastic disease or for inhibiting resistance to anticancer agents, containing the polypeptide.
A method of inhibiting autophagy in a cell, comprising administering to the cell a polypeptide consisting of the amino acid sequence of
A method for treating a neoplastic disease comprising administering to a subject in need thereof a pharmaceutical compositing comprising a polypeptide consisting of the amino acid sequence of X3-X1-T-X1-K-X2,
A method for inhibiting resistance to anticancer agents, comprising a polypeptide consisting of the amino acid sequence of X3-X1-T-X1-K—X2,
Dependencies are inferred from the claim text.