Affinity support and method for isolating immunoglobulin
AssigneesJsr Corporation, Jsr Life Sciences Corporation
InventorsTakashi Ichii, Satoshi Nakamura, Jun-ichi Yasuoka, Kaori Itaya, Tomonori Shiotani
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Abstract
To provide an affinity support in which a binding property of a ligand to a target substance is improved. The affinity support contains a solid phase support and a protein ligand, wherein the protein ligand is represented by formula (1): R—R1 (1) wherein R represents a linker binding to the solid phase support, which contains a polyproline, and R1 represents a protein showing an affinity to immunoglobulin, and the R is bound to a C terminal or an N terminal of an amino acid sequence in R1.
Claims10
An affinity support, comprising:
- a solid phase support and
- a protein ligand,
- wherein the protein ligand has the following formula(1):
- R—R1 (1),
- wherein
- R is a linker binding to the solid phase support, which comprises a polyproline comprising from 12 to 24 proline residues, and
- R1 is a protein having an affinity to an immunoglobulin, and
- R is bound to a C terminal or an N terminal of an amino acid sequence of the protein R1.
An affinity ligand, comprising:
- a linker R and
- a protein ligand R1,
- wherein
- the linker R comprises a polyproline comprising from 12 to 24 proline residues,
- R1 is a protein having an affinity to an immunoglobulin, and
- R is bound to a C terminal or an N terminal of an amino acid sequence of the protein R1.
Dependencies are inferred from the claim text.