Piperidine derivatives as inhibitors of ubiquitin specific protease 7

A compound of formula (I):

• or a pharmaceutically acceptable salt, tautomer, stereoisomer or N-oxide derivative thereof, wherein:
• R1 is H, OH or an optionally substituted alkyl group;
• R2 is an optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 alkynyl, optionally substituted C3-C6 cycloalkyl, optionally substituted C4-C6 alkylcycloalkyl, optionally substituted C4-C6 aryl, optionally substituted C3-C6 heteroaryl, optionally substituted C4-C8 aryloxy, optionally substituted C7-C10 arylalkyl or optionally substituted C5-C10 heteroarylalkyl group;
• and
• Q is selected from the group consisting of:
• wherein:
• R5a is H, halo, optionally substituted C1-C6 alkyl, or optionally substituted amino;
• R5b is H, halo, optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkynyl, benzyl, optionally monosubstituted C3-C6 heteroaryl, optionally substituted C3-C6 heterocycloalkyl, optionally substituted C1-C6 alkoxy, NR′R″, or RaNR′R″,
• wherein Ra is C1-C6 alkyl or C2-C6 alkenyl;
• and
• wherein R′ and R″ are each independently selected from H, oxo-substituted C1-C6 alkyl, hydroxy-substituted C1-C6 alkyl, optionally substituted C1-C6 alkoxy, optionally substituted C3-C6 cycloalkyl, optionally substituted C1-C7 alkylamine, optionally substituted C2-C7 alkenylamine, optionally substituted C3-C10 heterocycloalkyl, optionally substituted C4-C10 aryl, optionally substituted C3-C10 heteroaryl, optionally substituted C5-C10 alkylaryl, optionally substituted C4-C10 alkylheterocycloalkyl, and C4-C6 alkylheteroaryl, or wherein R′ and R″ together form an optionally substituted C3-C8 heterocycloalkyl including the N to which they are attached;
• R6a is H, optionally substituted C1-C6 alkyl, optionally substituted amino, optionally substituted C4-C6 aryl, optionally substituted C1-C6 sulfide, optionally substituted C1-C6 sulfonyl, or optionally substituted amino;
• R6b is H, cyano, halo, optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 alkynyl, optionally substituted C3-C6 cycloalkyl, optionally substituted C4-C6 cycloalkenyl, optionally substituted C2-C6 ynol, optionally substituted C4-C6 aryl, optionally substituted C3-C6 heteroaryl, optionally substituted amino;
• R7a is H;
• R7b is H or optionally substituted C4-C6 aryl;
• or wherein R7a and R7b together form an optionally substituted C1-C6 aryl group together with the carbons to which they are attached;
• R8a is H or is optionally substituted C4-C6 aryl;
• R9a is Cl, F, Br, I, or cyano;
• and
• R9b is H, optionally substituted C1-C6 alkyl, optionally substituted C4-C6 aryl, optionally substituted C3-C8 heteroaryl, C1-C6 alkoxy.