Back to results
US 10,766,902 B2Granted
Wee-1 inhibiting pyrazolopyrimidinone compounds
AssigneeAlmac Discovery Limited
InventorsFrank Burkamp, James Samuel Shane Rountree, Adam Piotr Treder
Life of this patent
Estimating the term…
Abstract
The present invention relates to pyrazolopyrimidinone derivatives, such as those of Formula (I), that are useful as inhibitors of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer
Claims26
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, or an optionally substituted heteroaryl group;
- R2 is an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, or an optionally substituted heteroaryl group,
- or R1, R2 and the sulphur atom to which they are both attached, as taken together, form an optionally substituted heterocyclyl group;
- R4 is an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, or an optionally substituted aryl group;
- R5 is an optionally substituted aryl group, an optionally substituted heteroaryl group, or an optionally substituted cycloalkyl group;
- R6 is a hydrogen atom or an optionally substituted aryl group;
- Y is a phenyl group or a five- or six-membered heteroaryl group.
5 more elements
A compound of Formula (II):
- or a pharmaceutically acceptable salt thereof, wherein:
- R2 is an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, or an optionally substituted heteroaryl group;
- R3 is a hydrogen atom, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, a cyano group, an optionally substituted alkanoyl group, an optionally substituted aroyl group, an optionally substituted heteroaroyl group, an optionally substituted alkoxy-carbonyl group, or an optionally substituted alkylamino-carbonyl group;
- R4 is an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, or an optionally substituted aryl group;
- R5 is an optionally substituted aryl group, an optionally substituted heteroaryl group, or an optionally substituted cycloalkyl group;
- R6 is a hydrogen atom or an optionally substituted aryl group;
- Y is a phenyl group or a five- or six-membered heteroaryl group.
4 more elements
A compound, or a pharmaceutically acceptable salt thereof, wherein the compound is:
- (90) 6-{[4-(Azetidin-1-yl)phenyl]amino}-1-(6-{[dimethyl(oxo)-λ6-sulfanylidene]amino}pyridin-2-yl)-2-(prop-2-en-1-yl)-1H,2H,3H-pyrazolo[3,4-d]pyrimidin-3-one.
Dependencies are inferred from the claim text.