Aryl-2,2′-tandem bisthiazole compound and preparation method and use thereof

A compound of formula I or an optical isomer thereof, or a pharmaceutically acceptable salt thereof:

• wherein,
• R1 is selected from the group consisting of H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, and C5-C10 aryl;
• and R2 is selected from the group consisting of C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, and C5-C10 aryl;
• or
• R1 is selected from the group consisting of C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, and C5-C10 aryl;
• and R2 is selected from the group consisting of H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, and C5-C10 aryl;
• or R1 and R2 together with the carbon atom to which they are attached form a 5-7 membered saturated or partially saturated ring;
• R3 is selected from the group consisting of H, C1-C6 alkyl, C3-C6 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, and C5-C10 aryl;
• and
• R4 is selected from the group consisting of C1-C6 alkyl, C3-C6 cycloalkyl, C2-C6 alkenyl and C2-C6 alkynyl;
• wherein the C1-C6 alkyl, C3-C6 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, or C5-C10 aryl is unsubstituted or substituted with one or more groups selected from the group consisting of halogen, C1-C6 alkyl, halogenated C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, halogenated C1-C6 alkoxy, C3-C6 cycloalkyl, and C5-C10 aryl.