Cyclin dependent kinase inhibitors

A compound of Formula (XI):

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is H, F, Cl, CN, C1-C2 alkyl or C1-C2 fluoroalkyl, where each said C1-C2 alkyl and C1-C2 fluoroalkyl is optionally substituted by R20;
• R2 is H, C1-C5 alkyl, C1-C5 fluoroalkyl, C3-C8 cycloalkyl or 3-6 membered heterocyclyl, where each said C1-C5 alkyl and C1-C5 fluoroalkyl is optionally substituted by R20 and each said C3-C8 cycloalkyl and 3-6 membered heterocyclyl is optionally substituted by R21;
• R4 is H, C1-C4 alkyl, C1-C4 fluoroalkyl, C1-C4 alkoxy or C1-C4 fluoroalkoxy, where each said C1-C4 alkyl, C1-C4 fluoroalkyl, C1-C4 alkoxy and C1-C4 fluoroalkoxy is optionally substituted by R20;
• or
• R2 can be taken together with R4 to form a 5-7 membered heterocyclic ring, optionally containing an additional heteroatom selected from NR24, O and S(O)m as a ring member, which ring is optionally substituted by R21;
• R6 is H, F, Cl, CN, CH3, CH2F, CHF2 or CF3;
• R7 and R8 are independently H, F, Cl, CN, C1-C2 alkyl, C1-C2 fluoroalkyl, C1-C2 alkoxy or C1-C2 fluoroalkoxy, where each said C1-C2 alkyl, C1-C2 fluoroalkyl, C1-C2 alkoxy and C1-C2 fluoroalkoxy is optionally substituted by R20;
• R9 is H, OH, NH2, NHCH3 or N(CH3)2;
• each R10 is independently F, CN, C1-C2 alkyl or C1-C2 fluoroalkyl, where each said C1-C2 alkyl and C1-C2 fluoroalkyl is optionally substituted by R20;
• each R20 is independently OH, C1-C2 alkoxy, C1-C2 fluoroalkoxy, CN or NR22R23;
• each R21 is independently F, OH, CN, NR22R23, C1-C4 alkyl, C1-C4 fluoroalkyl, C1-C4 alkoxy or C1-C4 fluoroalkoxy, where each said C1-C4 alkyl, C1-C4 fluoroalkyl, C1-C4 alkoxy and C1-C4 fluoroalkoxy is optionally further substituted by OH, NH2, NHCH3 or N(CH3)2;
• each R22 and R23 is independently H, C1-C2 alkyl or C1-C2 fluoroalkyl;
• or
• R22 and R23 may be taken together with the nitrogen atom to which they are attached to form an azetidinyl ring, which is optionally substituted by F or OH;
• R24 is H, C1-C4 alkyl, C1-C4 fluoroalkyl, SO2R25, SO2NR26R27, COR28, COOR28 or CONR29R30;
• R25 is C1-C4 alkyl or C1-C4 fluoroalkyl;
• each R26 and R27 is independently H or CH3;
• R28 is C1-C4 alkyl or C1-C4 fluoroalkyl, where each said C1-C4 alkyl and C1-C4 fluoroalkyl is optionally substituted by OH, C1-C2 alkoxy, C1-C2 fluoroalkoxy, CN, NH2, NHCH3 or N(CH3)2;
• each R29 and R30 is independently H, C1-C4 alkyl or C1-C4 fluoroalkyl, where each said C1-C4 alkyl and C1-C4 fluoroalkyl is optionally substituted by OH, C1-C2 alkoxy, C1-C2 fluoroalkoxy, CN, NH2, NHCH3 or N(CH3)2;
• m is 0, 1 or 2;
• and
• n is 0, 1, 2, 3 or 4.