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US 10,766,883 B2Granted
Aminopyrazoles as janus kinase inhibitors
AssigneeMerck Sharp & Dohme Corp.
InventorsPeter Fuller, Jason Brubaker, Hongbo Zeng, Joshua Close, Jonathan Young
Life of this patent
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Abstract
The instant invention provides compounds which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
Claims20
A compound selected from:
- 3-((4-Chloro-3-methoxyphenyl)amino)-1-(4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide;
- 3-((4-chloro-3-(methylthio)phenyl)amino)-1-(4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide;
- 3-((4-cyano-3-methoxyphenyl)amino)-1-(4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide;
- 3-((4-cyano-3-(2-fluoropropan-2-yl)phenyl)amino)-1-(4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide;
- and
- 1-(4-cyanotetrahydro-2H-pyran-3-yl)-3-((3-methylbenzo[d]isoxazol-5-yl)amino)-1H-pyrazole-4-carboxamide;
- or a pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.