Back to results
US 10,766,878 B2Granted
Sulfonylcycloalkyl carboxamide compounds
AssigneeGenentech, Inc.
InventorsBaihua Hu, Vishal Verma, Matthew Volgraf, Anthony Estrada, Joseph Lyssikatos
Life of this patent
Estimating the term…
Abstract
The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
Claims23
A compound of formula (I) or a pharmaceutically acceptable salt thereof:
- wherein:
- n is 2 or 3;
- R1 is aryl or heteoraryl, each optionally substituted with one or more groups independently selected from halogen, —CN, —C1-6 alkyl and —C1-6 haloalkyl;
- m is 0, 1, 2, or 3;
- each R2 is independently selected from halogen, —C1-6 alkyl, —C1-6 haloalkyl, —O—C1-6 alkyl, —C3-7 cycloalkyl, and —CN;
- R3 is an amide selected from the orientation —NH—C(O)— and —C(O)—NH—;
- R4 is a 4, 5, 6 or 7-membered heterocycle, aryl or heteroaryl optionally substituted with one or more groups independently selected from halogen, —C1-6 alkyl, —C1-6 haloalkyl, —O—C1-6 haloalkyl, and —CN;
- A is selected from A1, A2 and A3 wherein:
- A1 is unsubstituted or substituted 5-membered heteroaryl comprising one or two nitrogen hetero atoms;
- A2 is unsubstituted or substituted aryl;
- and
- A3 is unsubstituted or substituted 6-membered heteroaryl comprising one or two hetero nitrogen atoms;
- and
- each * independently denotes a chiral center (i) in an R configuration or in an S configuration or (ii) a mixture of R and S configurations for a plurality of compounds of formula (I).
11 more elements
A compound selected from:
A compound selected from:
A compound selected from:
Dependencies are inferred from the claim text.