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US 10,766,872 B2Granted
Compounds for the treatment of mycobacterial infections
AssigneeThe Board Institute, Inc.
InventorsDeborah Hung, Sarah Stanley, Tomohiko Kawate, Noriakie Iwase, Motohisa Shimizu
Life of this patent
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Abstract
The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof:
Claims11
A compound of Formula I or a pharmaceutically acceptable salt thereof:
- wherein:
- R1 is selected from the group consisting of phenyl, substituted phenyl, pyridinyl, and substituted pyridinyl;
- R3 is hydrogen, substituted C1-C8 alkyl, or unsubstituted C1-C8 alkyl;
- R4 is hydrogen, substituted C1-C8 alkyl, or unsubstituted C1-C8 alkyl;
- R2 is
- R6 and R7 are each independently selected from the group consisting of hydrogen and unsubstituted C1-C8 alkyl;
- R5 is selected from the group consisting of
- R100 and R100′ are each independently hydrogen or unsubstituted C1-C8 alkyl;
- R101 and R102 are each independently hydrogen or unsubstituted C1-C8 alkyl;
- wherein the term “substituted” refers to the replacement of one or more hydrogen radicals in a given structure with the radical selected from halo, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, thiol, alkylthio, arylthio, alkylthioalkyl, arylthioalkyl, alkylsulfonyl, alkylsulfonylalkyl, arylsulfonylalkyl, alkoxy, aryloxy, aralkoxy, aminocarbonyl, alkylaminocarbonyl, arylaminocarbonyl, alkoxycarbonyl, aryloxycarbonyl, haloalkyl, amino, cyano, nitro, alkylamino, arylamino, alkylaminoalkyl, arylaminoalkyl, aminoalkylamino, hydroxy, alkoxyalkyl, carboxy, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonylalkyl, acyl, and aralkoxycarbonyl.
7 more elements
Dependencies are inferred from the claim text.