Monocarboxylate transport modulators and uses thereof

A compound having the formula:

• or a pharmaceutically acceptable salt thereof,
• wherein:
• 1) n is 0;
• W is a bond;
• X is CH2;
• and
• B is selected from:
• or
• 2) n is 1;
• W is a bond;
• X is —NCH3;
• and
• B is selected from:
• R1 is selected from the group consisting of halogen, —CHF2, —CF3, —NO2, —CN, —C(O)R″, —C(O)OR″, —SO2R″, —C(O)NR″2, —C(O)N(OR″)R″ and
• R4 is selected from the group consisting of
• (a) —C(O)R″, —O(CH2)0-4R″, —(CH2)0-4C(O)R″, —(CH2)0-4C(O)OR″, —NR″2, —(CH2)0-4C(O)NR″2, —(CH2)0-4S(O)R″, —(CH2)0-4S(O)2R″, or —N(OR″)R″;
• and
• (b) a group selected from
• (1)
• (2) a 3-8 membered saturated or partially unsaturated cycloalkyl ring,
• (3) a 3-8 membered saturated or partially unsaturated heterocycloalkyl ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur,
• (4) phenyl, and
• (5) a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• and
• R″ is hydrogen or an optionally substituted group selected from:
• (a) C1-6 alkyl or C3-6 cycloalkyl;
• (b) a 3-8 membered saturated or partially unsaturated cycloalkyl ring formed from two R″;
• (c) a 3-8 membered saturated or partially unsaturated heterocycloalkyl ring formed from two R″ having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• (d) phenyl;
• and
• (e) a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur,
• or
• 3) n is 0;
• W is C(O);
• X is —NR5— or —CH2—, wherein R5 is hydrogen or C1-C3 alkyl;
• B is selected from the group consisting of phenyl;
• phenyl substituted with halogen, C1-C3 alkoxy, and trifluoromethyl;
• cyclohexyl;
• thiazolyl;
• oxazolyl;
• di(C1-C3 alkyl)pyrazolyl;
• thiophenyl;
• tetrahydropyranyl;
• pyridinyl;
• and N-(C1-C3 alkyl)piperidinyl;
• R1 is halogen, trifluoromethyl, cyano, or
• wherein
• represents azetidinyl, pyrrolidinyl, piperidinyl or azepinyl;
• and
• R4 is selected from the group consisting of: