US 10,766,857 B2 · Compound having BLT inhibitory activity and composition, for preventing or treating inflammatory diseases, comprising same as active ingredient

Abstract

The present invention relates to a novel compound showing leukotriene B4 receptor 2 (BLT2) inhibitory activity and a pharmaceutical composition, for preventing or treating inflammatory diseases, having same as an active ingredient. The inventors identified a novel compound containing BTL2 inhibitory activity, and experimentally confirmed that the present novel compound had an excellent effect on the enhancement of the cancer cell death, on the inhibition of the metastasis and chemotactic mobility, and on the anti-asthma activity. Therefore, the present novel compound can be used as a very effective pharmaceutical component for treating the inflammatory-related diseases.

Claims11

Dependent claims

A method for inhibiting or treating an inflammatory disease in a subject in need thereof, comprising:

administering to the subject an effective amount of a pharmaceutical composition comprising a compound represented by Formula 1 or a pharmaceutically acceptable salt thereof:
wherein,
R1 is C1 to C10 alkyl;
R2 is
wherein,
Ra is
or hydroxy;
Rb is
Rc is
Rd is hydrogen or and
and
Re is
and
R3 is hydrogen or fluorine and;
wherein the inflammatory disease is one that is responsive to inhibition of leukotriene B4 receptor 2 (BLT2) activity.

12 more elements

Dependencies are inferred from the claim text.

Facts

Application

16/181,953Filed 6 Nov 2018 · division

Priority

KR 10-2015-010509724 Jul 2015

Published

US 2019/0071395 A17 Mar 2019

Granted

8 Sep 2020

Term ends

Not estimatedThe source records don’t support an estimate.

Classification21 codes

C07C 311/21
Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings: having the nitrogen atom of at least…
A61P 11/06
Drugs for disorders of the respiratory system: antiasthmatics
A61P 35/00
Antineoplastic agents
C07C 233/07
With carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton: having the nitrogen atom of at…

Family

PCT/KR2016/008069Parent of this division · filed 23 Jul 2016

US 2019/0071395 A1Pre-grant publication · published 7 Mar 2019

Application15/745,337Parent of this division

US 10,179,764 B2Parent of this division

US 2018/0201573 A1Published application

US 10,766,857 B2This patent

From the US filing history. Foreign family members aren’t listed.

Compound having BLT inhibitory activity and composition, for preventing or treating inflammatory diseases, comprising same as active ingredient

Life of this patent

Compound having BLT inhibitory activity and composition, for preventing or treating inflammatory diseases, comprising same as active ingredient

Life of this patent

Abstract

Claims11