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US 10,766,029 B2Granted
Device, platform, and assay for assessing cells
AssigneeCells for Cells S.A.
InventorJuan Pablo Acevedo Cox
Life of this patent
Estimating the term…
Abstract
Devices are for assessing the migration response in the presence of a stable encapsulated gradient of a factor or factor combination, and quantifying the adherence response inside micro-channels in the presence of different factors. A platform is for obtaining information relating to migration score or the quantification of adhered cells through use of the devices, and it allows this information to be used to assess therapeutic potential. A method quantifies the cells migration response and the cell adherence response.
Claims21
A device adapted to assess cell migration responses of a population of cells, the device comprising:
- a) a cell load chamber;
- b) at least two migration assay lanes or lines formed by two parallel hydrogel side bands and allowing migration, wherein the migration assay lanes or lines are parallel, wherein a migration area in each assay lane is delimited in a lower part by the two side bands and material capable of supporting the two side bands and allowing migration, wherein the assay lanes or lines are open in an upper part and the migration is produced on the material;
- and
- c) wherein the hydrogel comprises an encapsulated migration inducing factor.
1 more element
Dependencies are inferred from the claim text.