US 10,765,888 B2Granted

System and method for automatic treatment planning

AssigneeElekta Limited

InventorsJens Olof Sjolund, Xiao Han

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Abstract

The present disclosure relates to systems, methods, and computer-readable storage media for radiotherapy. Embodiments of the present disclosure may receive a plurality of training data and determine one or more predictive models based on the training data. The one or more predictive models may be determined based on at least one of a conditional probability density associated with a selected output characteristic given one or more selected input variables or a joint probability density. Embodiments of the present disclosure may also receive patient specific testing data. In addition, embodiments of the present disclosure may predict a probability density associated with a characteristic output based on the one or more predictive models and the patient specific testing data. Moreover, embodiments of the present disclosure may generate a new treatment plan based on the prediction and may use the new treatment plan to validate a previous treatment plan.

Claims22

Dependent claims

A radiotherapy system for treating a target patient according to a treatment plan, the system configured to use training data associated with past treatment plans used to treat sample patients, the training data including a plurality of observations associated with conditions of the sample patients and derived from medical image data associated with the sample patients, the training data further including one or more plan outcomes reflecting outcomes resulting from the past treatment plans, or plan parameters reflecting design parameters of the past treatment plans, the system comprising:

a processing device configured to generate the treatment plan, the processing device configured to execute instructions stored on a computer-readable medium that, upon execution, cause the processing device to perform operations including:
determining a joint probability density indicating a likelihood that both at least one particular observation and at least one particular plan outcome of the one or more plan outcomes or plan parameter of the plan parameters are present in the training data;
calculating a conditional probability based upon the determined joint probability density, wherein the conditional probability indicates a likelihood that the at least one particular plan outcome or the plan parameter is present in the training data;
predicting a probability of a patient specific plan outcome or patient specific plan parameter based on the conditional probability and at least one patient specific observation associated with the target patient and derived from medical image data associated with the target patient;
generating the treatment plan based on the prediction;
and
controlling a radiotherapy device to perform radiotherapy treatment according to the generated treatment plan.

4 more elements

A method for treating a target patient according to a treatment plan acid for use with training data associated with past treatment plans used to treat sample patients, the training data including a plurality of observations associated with conditions of the sample patients and derived from medical image data associated with the sample patients, the training data further including one or more plan outcomes reflecting outcomes resulting from the past treatment plans, or plan parameters reflecting design parameters of the past treatment plans, the method comprising:

determining a joint probability density indicating a likelihood that both at least one particular observation and at least one particular plan outcome or plan parameter are present in the training data;
calculating a conditional probability based upon the determined joint probability density, wherein the conditional probability indicates a likelihood that the at least one particular plan outcome or the plan parameter is present in the training data;
predicting a probability of a patient specific plan outcome or plan parameter based on the conditional probability and at least one patient specific observation associated with the target patient and derived from medical image data associated with the target patient;
generating the treatment plan based on the prediction;
and
controlling a radiotherapy device to perform radiotherapy treatment according to the generated treatment plan.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application: 16/029,147Filed 6 Jul 2018 · continuation
Priority: 18 Jun 2014
Published: US 2018/0311510 A11 Nov 2018
Granted: 8 Sep 2020
Term ends: Not estimatedThe source records don’t support an estimate.

Classification11 codes

A61N 5/1038
Treatment planning systems: taking into account previously administered plans applied to the same patient, i.e. adaptive radiotherapy
A61B 6/032
Computed tomography [CT]: transmission computed tomography [CT]
A61N 5/103
X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy: treatment planning systems
A61N 5/1039
Treatment planning systems: using functional images, e.g. PET or MRI

Family

Application14/308,450Parent of this continuation · filed 18 Jun 2014
US 2018/0311510 A1Pre-grant publication · published 1 Nov 2018
US 10,046,177 B2Parent of this continuation
US 2015/0367145 A1Published application
US 10,765,888 B2This patent

From the US filing history. Foreign family members aren’t listed.

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