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US 10,765,881 B2Granted
Magnetic particle conjugates and methods of activating cell signaling
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsJon P. Dobson, Josephine Allen
Life of this patent
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Abstract
Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, and the like.
Claims15
A method of activating cell signaling, comprising:
- introducing a magnetic particle conjugate to a subject, wherein the magnetic particle conjugate includes a magnetic core and a nucleic acid aptamer attached to the magnetic core, wherein the aptamer has an affinity for a target cell, wherein the magnetic particle conjugate binds to the target cell, wherein the binding of the magnetic particle to the target cell does not cause activation of the specific biochemical signaling cascade in the target cell;
- and
- subjecting the magnetic particle conjugate to a magnetic field, wherein application of the magnetic field causes an energy transfer from the magnetic field to the magnetic particle to the target cell activating a specific biochemical signaling cascade in the target cell.
A composition comprising:
- a magnetic particle conjugate having a magnetic core and a nucleic acid aptamer attached to the magnetic core, wherein the aptamer has an affinity for a target cell, wherein the magnetic core is selected from the group consisting of:
- iron sulfide, strontium ferrite, barium ferrite, and cobalt ferrite.
A composition comprising:
- a magnetic particle conjugate having a magnetic core and a nucleic acid aptamer attached to the magnetic core, wherein the aptamer has an affinity for a target cell, wherein the magnetic core is selected from the group consisting of:
- γFe2O3 and αFe2O3, wherein the nucleic acid aptamer is selected from the group consisting of aptamers targeting:
- transforming growth factor-β receptor, vascular endothelial growth factor receptor, bone morphogenic protein receptor, and voltage-gated, ligand-gated or mechanosensitive ion channels.
Dependencies are inferred from the claim text.