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US 10,765,801 B2Granted
Drug delivery device with proximity sensor
AssigneeAmgen Inc.
InventorAdam B. McCullough
Life of this patent
Estimating the term…
Abstract
A drug delivery device, in the form of an injector, may include one of a number of systems for limiting the delivery of a medical fluid or drug product in case of movement of (e.g., removal of) the injector relative to the patient as determined by a proximity sensor. The drug delivery system may in the alternative or in addition include systems for indicating the amount of medical fluid or drug product delivered (or not delivered) in case of movement of (e.g., removal of) the injector relative to the patient as determined by the proximity sensor. The injector may be, for example, an on-body injector or an hand-held autoinjector.
Claims36
An on-body injector comprising:
- a reservoir including a bore having a first end and a second end, and a plunger assembly including a plunger moveable within the bore between the first and second ends;
- a cannula having an operational state wherein the cannula is connected in fluid communication with the reservoir;
- a drive coupled to the plunger assembly to move the plunger between the first and second ends for moving a drug product out of the reservoir and through the cannula;
- a housing, wherein the reservoir, the cannula, and the drive are disposed at least partially within the housing;
- a proximity sensor operably coupled to move relative to the housing, the proximity sensor having a first sensor state wherein the proximity sensor extends from the housing and a second sensor state wherein the proximity sensor is retracted toward the housing relative to the first sensor state;
- a biasing member configured to bias the proximity sensor toward the first sensor state;
- and
- a lock operably coupled to the proximity sensor, the lock having a first position resisting movement of the plunger between the first and second ends of the reservoir when the proximity sensor is in the first sensor state and the lock having a second position permitting movement of the plunger between the first and second ends of the reservoir when the proximity sensor is in the second sensor state.
5 more elements
An on-body injector comprising:
- a reservoir including a bore having a first end and a second end, and a plunger assembly including a plunger moveable within the bore between the first and second ends;
- a cannula having an operational state wherein the cannula is connected in fluid communication with the reservoir;
- a drive coupled to the plunger assembly to move the plunger between the first and second ends for moving a drug product out of the reservoir and through the cannula;
- a housing, wherein the reservoir, the cannula, and the drive are disposed at least partially within the housing;
- a proximity sensor operably coupled to move relative to the housing, the proximity sensor having a first sensor state wherein the proximity sensor extends from the housing and a second sensor state wherein the proximity sensor is retracted toward the housing relative to the first sensor state;
- and
- an indicator disposed at an exterior surface of the housing, the indicator being operable to track movement of the plunger within the bore of the reservoir when the proximity sensor is in the second sensor state and not being operable to track movement of the plunger within the bore of the reservoir when the proximity sensor is in the first sensor state.
4 more elements
An on-body injector comprising:
- a reservoir including a bore having a first end and a second end, and a plunger assembly including a plunger moveable within the bore between the first and second ends and a plunger arm attached to the plunger;
- a cannula having an operational state wherein the cannula is connected in fluid communication with the reservoir;
- a drive coupled to the plunger assembly to move the plunger between the first and second ends for moving a drug product out of the reservoir and through the cannula;
- a housing, wherein the reservoir, the cannula, and the drive are disposed at least partially within the housing;
- a proximity sensor operably coupled to move relative to the housing, the proximity sensor having a first sensor state wherein the proximity sensor extends from the housing and a second sensor state wherein the proximity sensor is retracted toward the housing relative to the first sensor state;
- a gear train including at least one gear that is moveable into and out of engagement with the plunger arm;
- and
- an indicator mechanically coupled to the plunger arm via the at least one gear when the proximity sensor is in the second sensor state, the proximity sensor being coupled to the at least one gear to move the at least one gear out of engagement with the plunger arm and mechanically decouple the indicator from the plunger arm when the proximity sensor is in the first sensor state.
5 more elements
An on-body injector comprising:
- a reservoir including a bore having a first end and a second end, and a plunger assembly including a plunger moveable within the bore between the first and second ends;
- a volume of a drug product disposed in the reservoir, the drug product comprising a granulocyte colony-stimulating factor (G-CSF);
- a cannula having an operational state wherein the cannula is connected in fluid communication with the reservoir;
- a drive coupled to the plunger assembly to move the plunger between the first and second ends for moving the drug product out of the reservoir and through the cannula;
- a housing, wherein the reservoir, the cannula, and the drive are disposed at least partially within the housing;
- a proximity sensor operably coupled to move relative to the housing, the proximity sensor having a first sensor state wherein the proximity sensor extends from the housing and a second sensor state wherein the proximity sensor is retracted toward the housing relative to the first sensor state;
- an indicator selectively coupled to the plunger assembly when the proximity sensor is in the second sensor state and selectively de-coupled from the plunger assembly when the proximity sensor is in the first sensor state, wherein the indicator is mechanically coupled to the plunger assembly when the proximity sensor is in the second sensor state;
- and wherein the plunger assembly comprises a plunger arm attached to the plunger, the indicator being selectively mechanically coupled to the plunger arm through a gear train having at least one gear that is moveable into and out of engagement with the plunger arm, and the proximity sensor is coupled to the at least one gear to move the at least one gear out of engagement with the plunger arm and decouple the indicator from the plunger arm with the proximity sensor in the first sensor state.
5 more elements
Dependencies are inferred from the claim text.