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US 10,765,779 B2Granted
Medical implant
AssigneeThe University of Sheffield
InventorsAileen Crawford-Corrie, David John Buttle, John William Haycock
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AssigneeThe University of Sheffield
InventorsAileen Crawford-Corrie, David John Buttle, John William Haycock
Estimating the term…
The present invention relates to a cell-free, multi-layered medical device having bespoke, multifunctional bioactivity for the purpose of regeneration of skeletal tissues. The medical device may actively promote homing of stem cells into the medical device and promote their differentiation into the required cell type and promote de-novo tissue formation. The invention includes methods of making the medical device, uses of the medical device in promoting regeneration of the articular cartilage of a joint surface and in promoting healing and regeneration of skeletal tissues, for example, meniscal cartilage, tendon and ligament tissues and also healing of bone tissue indications such as fractures.
An acellular biomimetic medical device comprising a scaffold coated in or adsorbed on its surfaces with a first layer comprising a cationic agent, the first layer being covered or coated with a second layer comprising an anionic oligosaccharide or polysulphated moiety, which is non-covalently bound to a mixture of a plurality of bioactive factors, wherein the plurality of bioactive factors comprises:
Dependencies are inferred from the claim text.