US 10,765,777 B2Granted

Light adjustable intraocular lenses using upconverting core-shell nanoparticles and near infrared (NIR) light

AssigneeCalifornia Institute of Technology

InventorsRobert H. Grubbs, Christopher B. Marotta

Life of this patent

Estimating the term…

Abstract

This disclosure relates compositions comprising upconverting core-shell nanocrystals and photoactive compositions and methods using these compositions to modify treat myopia and other ocular conditions. In some cases, the methods use near infrared irradiation to adjust the refractive power of light adjustable intraocular lenses.

Claims25

Dependent claims

A light adjustable intraocular lens comprising:

(a) a photopolymerizable prepolymer;
(b) a UV-Vis photoinitiator;
(c) at least one upconverting core-shell nanocrystal;
and
(d) optionally a UV-Vis blocker;
wherein the light adjustable intraocular lens further optionally comprises a polymer matrix in which the photopolymerizable prepolymer material, the UV-Vis photoinitiator, the optional UV-Vis blocker, and the at least one upconverting core-shell nanocrystal are distributed.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application: 16/020,196Filed 27 Jun 2018 · us provisional application
Priority: 28 Jun 2017
Published: US 2019/0001024 A13 Jan 2019
Granted: 8 Sep 2020
Term ends: Not estimatedThe source records don’t support an estimate.

Classification14 codes

A61L 27/44
Composite materials, i.e. containing one material dispersed in a matrix of the same or different material: having a macromolecular matrix
A61F 2/1627
Having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside: for…
A61F 2/1635
Having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside: for…
A61F 2/1659
Having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having…:…

Family

Application62/526,186Us provisional application · filed 28 Jun 2017
US 2019/0001024 A1Pre-grant publication · published 3 Jan 2019
US 10,765,777 B2This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

Facts

Application

16/020,196Filed 27 Jun 2018 · us provisional application

Priority

28 Jun 2017

Published

US 2019/0001024 A13 Jan 2019

Granted

8 Sep 2020

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

A61L 27/44
Composite materials, i.e. containing one material dispersed in a matrix of the same or different material: having a macromolecular matrix
A61F 2/1627
Having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside: for…
A61F 2/1635
Having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside: for…
A61F 2/1659
Having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having…:…