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US 10,765,763 B2Granted
Radioligands for myelin
AssigneeCase Western Reserve University
InventorsYanming Wang, Chunying Wu
Life of this patent
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Abstract
A radioligand for labeling myelin includes a fluorescent trans-stilbene derivative.
Claims14
A method of detecting myelin in vivo in a subject's tissue, the method comprising:
- (i) administering to the subject a radioligand including a compound having the formula:
- R2 is H, or NHR′, where R′ is a lower alkyl group;
- R3 is a radiolabeled lower alkyl group, alkylene group, alkenyl group, alkynyl group, or alkoxy group;
- wherein R3 includes a radiolabeled group having a radiolabel selected from the group consisting of 18F, 123I, 125I, and 99mTc;
- or a pharmaceutically acceptable salt thereof;
- and
- (ii) detecting the location, distribution, and/or amount of the radioligand that is bound to and/or labels myelin to detect myelin in the tissue.
4 more elements
A method of detecting a myelin related disorder in a subject in need thereof, the method comprising the steps of:
- (i) administering to the subject a radioligand that includes a compound having the formula:
- R2 is H, or NHR′, where R′ is a lower alkyl group;
- R3 is a radiolabeled lower alkyl group, alkylene group, alkenyl group, alkynyl group, or alkoxy group;
- wherein R3 includes a radiolabeled group having a radiolabel selected from the group consisting of 18F, 123I, 125I, and 99mTc;
- or a pharmaceutically acceptable salt thereof;
- (ii) detecting the distribution and/or amount of the radioligand in a region of interest in tissue of the subject;
- and
- (iii) comparing the detected distribution and/or amount of the radioligand to a control, wherein a decreased distribution and/or amount of the radioligand compared to the control is indicative of a decrease in myelination of the tissue and the presence of myelination related disorder.
5 more elements
Dependencies are inferred from the claim text.