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US 10,765,759 B2Granted
Methods of treating an ocular disease or disorder
AssigneeThe Regents of the University of California
InventorsKevin E. Healy, Eda Isil Altiok, David V. Schaffer, Wesley M. Jackson
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Abstract
The present disclosure provides methods of treating an ocular disease or disorder. The methods involve direct administration into the eye of a conjugate comprising a biologically active polypeptide and a biocompatible polymer.
Claims12
A method of treating an ocular disease or disorder in an individual, the method comprising administering to the individual an effective amount of a conjugate comprising:
- a) a biologically active polypeptide having a molecular weight of from about 5 kDa to about 250 kDa, wherein the biologically active polypeptide is a single-chain Fv (scFv) anti-vascular endothelial growth factor (VEGF) antibody or a single-domain camelid (VHH) anti-VEGF antibody;
- and
- b) a biocompatible polymer comprising hyaluronic acid having a molecular weight of from about 500 kDa to about 1 MDa,
- wherein the polypeptide is covalently linked to the polymer directly or via a linker, and wherein the molar ratio of the biologically active polypeptide to the polymer is at least 25:1,
- wherein said administering is by intravitreal administration.
2 more elements
Dependencies are inferred from the claim text.