Compositions and methods related to inhibition of respiratory syncytial virus entry
AssigneesNavigen, Inc., University of Utah Research Foundation
InventorsBrett D. Welch, Michael S. Kay, Debra Muir Eckert, Rena McKinnon, Michael Thomas Jacobsen
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Abstract
Disclosed herein are compositions and methods for inhibiting respiratory syncytial virus (RSV) entry into a host cell. Also provided herein are methods of identifying a peptide that interacts with the N-trimer of RSV F protein.
Claims36
An isolated D-peptide comprising the amino acid sequence of SEQ ID NO:42, wherein the amino acids of the D-peptide have a D-configuration with the exception of glycine and the D-peptide is capable of interacting with the N-trimer groove of respiratory syncytial virus (RSV) F protein.
An isolated composition comprising a first D-peptide comprising the amino acid sequence of SEQ ID NO:42, wherein the amino acids of the first D-peptide have a D-configuration with the exception of glycine and the first D-peptide is capable of interacting with the N-trimer groove of respiratory syncytial virus (RSV) F protein.
A method for inhibiting entry of RSV into a host cell, comprising exposing the RSV virus to a composition comprising a first D-peptide, a second D-peptide, and a third D-peptide that are multimerized through a scaffold having the following structure:
- wherein each of the first, second, and third D-peptides comprises an amino acid sequence as set forth in SEQ ID NO:142;
- or each of the first, second, and third D-peptides comprises an amino acid sequence as set forth in SEQ ID NO:214;
- and wherein the amino acids of the first, second, and third D-peptides have a D-configuration with the exception of glycine.
Dependencies are inferred from the claim text.