Pharmaceutical composition containing pyridylaminoacetic acid compound
AssigneeSanten Pharmaceutical Co., Ltd.
InventorYoko Endo
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Abstract
The purpose of the present invention is to provide a pharmaceutical composition that comprises a specific compound and exhibits a superior preservation efficacy, the specific compound being stable within the pharmaceutical composition, and to provide methods for improving the stability of the specific compound within the pharmaceutical composition and the preservation efficacy of the pharmaceutical composition. The pharmaceutical composition according to the present invention comprises isopropyl (6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino)acetate or a salt thereof, and further comprises edetic acid or a salt thereof.
Claims12
A pharmaceutical composition comprising isopropyl (6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino)acetate or a salt thereof and a nonionic surfactant, which further comprises edetic acid or a salt thereof,
- wherein the nonionic surfactant includes polyoxyethylene castor oil,
- wherein the pharmaceutical composition does not comprise sorbic acid;
- wherein the content of the nonionic surfactant is in a range of 0.001 to 5% (w/v), and
- wherein the content of the edetic acid or a salt thereof is in a range of 0.001 to 1% (w/v).
A method for stabilizing isopropyl (6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino)acetate or a salt thereof comprising adding edetic acid or a salt thereof and polyoxyethylene castor oil into a pharmaceutical composition comprising isopropyl (6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino)acetate or a salt thereof,
- wherein the pharmaceutical composition does not comp rise sorbic acid,
- wherein the content of the nonionic surfactant is in a range of 0.001 to 5% (w/v);
- and
- wherein the content of the edetic acid or a salt thereof is in a range of 0.001 to 1% (w/v).
Dependencies are inferred from the claim text.