US 10,765,748 B2 · Composition and methods for tethering bioactive peptides to metal oxide surfaces

Abstract

In various aspects, embodiments of the present invention are directed to a series of multivalent dendrons containing a bioactive peptide domain and surface-binding catechol domains. In some embodiments, these multivalent dendrons were obtained through solid phase synthesis and have a strong binding affinity to metal oxide surfaces such as, TiO2, ZrO2, CeO2, and Fe3O4, SiO2, as well as other inorganic surfaces such as hydroxyapatite, silver, fluorapatite, calcium carbonate and gold. These catechol-bearing dendrons provide a fast and efficient method to functionalize a wide range of inorganic materials with bioactive peptides and have the potential to be used in coating orthopaedic implants and fixation devices.

Claims20

Dependent claims

A multivalent dendron comprising a bioactive peptide domain and one or more surface-binding catechol domains and having the formula:

wherein PEP is a bioactive peptide domain of 2-30 amino acids having a specific biological function;
R is selected from the group consisting of —CH3, —(CH2)3NHC(NH2)C═NH, —CH2CONH2, —CH2COOH, —CH2SH, —(CH2)2COOH, —(CH2)2CONH2, —NH2, —CH2C═CH—N═CH—NH, —CH(CH3)CH2CH3, —CH2CH(CH3)2, —(CH2)4NH2, —(CH2)2SCH3, —CH2Ph, —CH2OH, —CH(OH)CH3, —CH2—C═CH—NH-Ph, —CH2-Ph-OH, —CH(CH3)2, and combinations thereof;
a is an integer from 1 to 20;
and m is 0 or 1.

1 more element

Dependencies are inferred from the claim text.

Composition and methods for tethering bioactive peptides to metal oxide surfaces

Life of this patent

Composition and methods for tethering bioactive peptides to metal oxide surfaces

Life of this patent

Abstract

Claims20