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US 10,765,744 B2Granted
Magnetic particle conjugates, micelles, and methods of delivering agents
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsCarlos Rinaldi, Sun Hao, Brent S. Sumerlin
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Abstract
Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, micelles (also referred to as a “magnetic composite nanocarrier” (MC-NC)), methods of making micelles, methods of using micelles, and the like.
Claims10
A composition comprising:
- a magnetic particle conjugate having a magnetic particle and a polymer attached to the magnetic particle, wherein the polymer includes an agent (Agent) bonded to the polymer through thermally degradable retro-Diels-Alder-agent group, wherein the polymer comprises:
- wherein w is 1 to 20, x is 0 to 20, y is 0 to 60, and z is 0 to 10, wherein the polymer is bonded to the magnetic particle on the left of the structure.
A composition, comprising:
- a micelle including a plurality a magnetic particle conjugate having a magnetic particle and a polymer attached to the magnetic particle, wherein the polymer has a hydrophobic region and a hydrophilic region, wherein the hydrophobic region of the polymer is located in a central region of the micelle and the hydrophilic region is located away from the central region and forms the micelle outer boundary, wherein the polymer includes an agent (Agent) bonded to the polymer through thermally degradable retro-Diels-Alder-agent group, wherein the polymer comprises:
- wherein w is 1 to 20, x is 0 to 20, y is 0 to 60, and z is 0 to 10, wherein the polymer is bonded to the magnetic particle on the left of the structure.
Dependencies are inferred from the claim text.