Compounds and methods for affecting cytokines
AssigneeZIVO Bioscience, Inc.
InventorAndrew Dahl
Life of this patent
Estimating the term…
Abstract
The present invention discloses isolates and fractions from a phyto-percolate and methods for affecting various cytokines by administering an effective amount of one or more of said isolates or fractions to an animal. In various exemplary embodiments, the isolates are useful for the treatment of bovine, canine and swine infection or inflammation, including bovine mastitis, by regulation of TNF-α, lactoferrin, IFN-γ, IL-1β, serum amyloid-A (SAA), IL-6 and/or β-defensin associated with infection or an immune response generally.
Claims16
A method of treating mastitis in a cow, said method comprising administering to said cow a therapeutically effective amount of one or more liquid fractions of a sterile bioactive liquid obtained by filtering an incubated culture of ATCC Deposit No. PTA-5863 through sterilizing membrane filters and subjecting the sterile filtrate to chromatographic fractionation, wherein said one or more liquid fractions up-regulate at least one anti-inflammatory cytokine in bovine mammary epithelial cells, and/or down-regulate at least one pro-inflammatory cytokine in bovine mammary epithelial cells.
A method of modulating an immune response in bovine, swine or canine, said method comprising the step of administering to said bovine, swine or canine an effective amount of one or more fractions of a sterile bioactive liquid obtained by filtering an incubated culture of ATCC Deposit No. PTA-5863 through sterilizing membrane filters and subjecting the sterile filtrate to chromatographic fractionation, wherein said immune response is characteristic of bovine mastitis, bovine respiratory disease complex, transition cow syndrome, canine osteoarthritis, canine skeletal-muscular overexertion, or porcine reproductive and respiratory syndrome virus immune disorder.
A method of promoting an antimicrobial response at a site of infection in an animal, said method comprising the step of administering to said animal an effective amount of one or more liquid fractions of a sterile bioactive liquid obtained by filtering an incubated culture of ATCC Deposit No. PTA-5863 through sterilizing membrane filters and subjecting the sterile filtrate to chromatographic fractionation.
Dependencies are inferred from the claim text.