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US 10,765,727 B2Granted
Compositions and methods for producing dendritic cells
AssigneePrimevax Immuno-Oncology, Inc.
InventorsBruce W. Lyday, Tony Chen
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Abstract
Described herein are compositions and methods for treating a disease, particularly a cancer, with primed dendritic cells recognizing a tumor antigen. The methods may comprise storing, shipping and/or culturing dendritic cells, where the dendritic cells are stored on a hard surface. Lysis protocols are described where the lysis does not result in complete lysis of cells in order to provide cell surface molecules maintained in a cell surface-embedded state. Non-lethal Dengue virus strains are also provided for therapeutic purposes.
Claims11
A method for treating or reducing melanoma, comprising:
- obtaining primed dendritic cells by a process comprising the steps of:
- contacting dendritic cells with a tumor antigen, lipopolysaccharide, R848, and interferon-gamma;
- administering the primed dendritic cells to a subject in need thereof;
- and
- administering a Dengue Virus to the subject, wherein the Dengue Virus is serotype 2 strain #1710, and wherein the subject has melanoma.
2 more elements
Dependencies are inferred from the claim text.