Unit dose formulation of antidotes for factor Xa inhibitors and methods of using the same
AssigneePortola Pharmaceuticals, Inc.
InventorsUma Sinha, Genmin Lu, Athiwat Hutchaleelaha, Stanley J. Hollenbach
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Abstract
The present invention relates unit dose formulations of antidotes to anticoagulants targeting factor Xa. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.
Claims20
A method for reversing anticoagulation in a subject undergoing an anticoagulant therapy with a factor Xa inhibitor, comprising administering to the subject from about 10 mg to about 2 grams of a two-chain polypeptide comprising a first chain comprising the amino acid sequence of SEQ ID NO:14 or a first polypeptide having at least 90% sequence identity to SEQ ID NO:14, and a second chain comprising the amino acid sequence of SEQ ID NO:15 or a second polypeptide having at least 95% sequence identity to SEQ ID NO:15, wherein the two-chain polypeptide has reduced catalytic activity as compared to the wild-type factor Xa protein, and is capable to bind to the factor Xa inhibitor.
Dependencies are inferred from the claim text.