Angiotensin II alone or in combination for the treatment of hypotension
AssigneeThe George Washington University a Congressionally Chartered Not-for-Profit Corporation
InventorLakhmir S. Chawla
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Abstract
The present invention relates, inter alia, to a method comprising administering to a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to at least about 0.2 mcg/kg/min of norepinephrine a dose of angiotensin II which is effective to raise the blood pressure of the subject to a mean arterial pressure (MAP) of about 65 mm Hg or above, and which is effective to reduce the dose of the catecholamine required to maintain a MAP of about 65 mm Hg to the equivalent of about 0.05-0.2 mcg/kg/min norepinephrine or less, or to the equivalent of about 0.05 mcg/kg/min norepinephrine or less.
Claims10
A method of treating a hypotensive human patient suffering from acute kidney injury, comprising administering angiotensin II to the patient at an initial rate of about 0.25 to 10 ng/kg/min and titrating the rate down to achieve and/or maintain a target mean arterial pressure (MAP) of at least about 65 mmHg in the patient.
A method of achieving a target mean arterial pressure (MAP) of at least about 65 mmHg in a hypotensive human patient experiencing acute kidney injury, comprising administering angiotensin II to the patient at an initial rate of about 0.25 to 10 ng/kg/min and titrating the rate down.
Dependencies are inferred from the claim text.