Methods for expansion or depletion of t-regulatory cells
AssigneeThe General Hospital Corporation
InventorDenise L. Faustman
Life of this patent
Estimating the term…
Abstract
The invention features methods of producing compositions enriched in Tregs and methods for treating immunological disorders using these compositions. The invention also features methods for producing compositions enriched in lymphocytes and depleted of Tregs and the use of these compositions in the treatment of proliferative disorders.
Claims10
A method of treating a proliferative disorder or an infectious disease in a subject comprising administering to said subject an isolated human, humanized, or chimeric antibody, or antigen-binding fragment thereof, that selectively binds to an epitope of TNFR2 that is bound by antibody clone MAB726 or by antibody clone M1.
Dependencies are inferred from the claim text.