Compositions and methods for delivering inhibitory oligonucleotides
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsBira Arya, Purevdorj Olkhanud, Juan Espinoza
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Abstract
The present invention features compositions and methods that make use of complexes comprising one or more inhibitory nucleic acids and a targeting polypeptide, wherein the targeting polypeptide consists of a cell surface receptor ligand. The compositions can be used in methods of silencing gene expression in a cell, delivering agents to a target cell, and in treating or preventing a disease or disorder in a subject.
Claims18
A fusion molecule comprising a targeting polypeptide, and a nucleic acid binding domain, wherein the targeting, polypeptide is selected from monocyte chemoattractant protein 1 (MCP-1/CCL-2), thymus- and activation-regulated chemokine (TARC/CCL17), Regulation upon Activation Normal T cell Express Sequence (RANTES/CCL5), and a receptor binding fragment of MCP-1, TARC, or RANTES, and the nucleic acid binding domain is amino acids 87 through 102 of SEQ ID NO:
- 11.
A fusion molecule comprising the amino acid sequence of SEQ ID NO:
- 11.
A fusion molecule comprising the amino acid sequence of SEQ ID NO:
- 9.
A fusion molecule comprising the amino acid sequence of SEQ ID NO:
- 10.
Dependencies are inferred from the claim text.